Search results for "betalamic acid"

showing 3 items of 3 documents

Synthesis and Antioxidative Properties of 1,2,3,4-Tetrahydropyridine Derivatives with Different Substituents in 4-Position

2022

Natural products are an excellent source of inspiration for the development of new drugs. Among them, betalains have been extensively studied for their antioxidant properties and potential application as natural food dyes. Herein, we describe the seven-step synthesis of new betalamic acid analogs without carboxy groups in the 2- and 6-position with an overall yield of ~70%. The Folin–Ciocalteu assay was used to determine the antioxidant properties of protected intermediate 21. Additionally, the five-step synthesis of betalamic acid analog 35 with three ester moieties was performed. Using NMR techniques, the stability of the obtained compounds towards oxygen was analyzed.

Folin–CiocalteuPyrrolidinesantioxidantPyridinesLemieux–Johnson oxidationOrganic ChemistryBetalainsPharmaceutical Scienceindicaxanthinsbetalamic acidAntioxidantsdehydrobrominationAnalytical ChemistryChemistry (miscellaneous)piperidin-4-onesDrug Discoverycis/trans diastereomersMolecular MedicineWittig reactionindicaxanthins; betalamic acid; antioxidant; dehydrobromination; TEMPO oxidation; (E)-(Z) configuration; piperidin-4-ones; <i>cis</i>/<i>trans</i> diastereomers; <i>Wittig</i> reaction; <i>Lemieux</i>–<i>Johnson</i> oxidation; Folin–CiocalteuPhysical and Theoretical ChemistryTEMPO oxidation(E)-(Z) configurationMolecules
researchProduct

Theoretical Determination Of The pKas Of Betalamic Acid Related To The Free-Radical Scavenger Capacity: Comparison Between Semi-Empirical And Ab Init…

2013

computational methodsfree-radical scavengerpKabetalamic acidSettore CHIM/08 - Chimica Farmaceutica
researchProduct

Theoretical Determination of the pK a Values of Betalamic Acid Related to the Free Radical Scavenger Capacity: Comparison Between Empirical and Quant…

2015

Health benefits of dietary phytochemicals have been suggested in recent years. Among 1000s of different compounds, Betalains, which occur in vegetables of the Cariophyllalae order (cactus pear fruits and red beet), have been considered because of reducing power and potential to affect redox-modulated cellular processes. The antioxidant power of Betalains is strictly due to the dissociation rate of the acid moieties present in all the molecules of this family of phytochemicals. Experimentally, only the pK a values of betanin were determined. Recently, it was evidenced it was evidenced as the acid dissociation, at different environmental pHs, affects on its electron-donating capacity, and fur…

AntioxidantPyridinesmedicine.medical_treatmentBetalainsHealth Informatics010402 general chemistry01 natural sciencesGeneral Biochemistry Genetics and Molecular BiologyAcid dissociation constantAntioxidantschemistry.chemical_compoundComputational chemistryBetalamic Acid antioxidants pKa predictions empirical methods DFTmedicineOrganic chemistryA valueMoleculeBetaninQuantum chemical010405 organic chemistryFree Radical ScavengersFree radical scavengerSettore CHIM/08 - Chimica Farmaceutica0104 chemical sciencesComputer Science ApplicationschemistryModels ChemicalBetalamic acid
researchProduct